Whole blood microRNA expression in lung adenocarcinoma cases and controls.

<p><i>A</i>. Unsupervised clustering of the 45 samples of this study by log₂-transformed microarray signal values of all 395 expressed microRNAs. The numbers indicate identities of the 45 subjects, with cases (n = 22) and controls (n = 23) shown in black and grey, respectively. The sample tree with optimized leaf-ordering is drawn using Pearson correlation for distance metric and average linkage for cluster-to-cluster distance, and the scale for it represents node-heights. <i>B</i>. Supervised clustering of microRNAs by their log₂-transformed microarray signal values. The heat-map, with the pseudo-color scale underneath, shows log₂-transformed microarray signal values of the 43 microRNAs whose expression is altered >25% in either direction in the cases compared to the controls. The gene tree is drawn as in <i>A</i>.