Distribution of PolyPhen-2 (panels A, C, E) and SIFT (panels B, D, F) calls for mutations in DM, Poly and NES datasets.

<p>Both predictors show a drop in sensitivity for disease mutations in IDR and D<b><i>→</i></b>D categories (A, B) and a drop in specificity for D<b><i>→</i></b>O mutations in Poly (C, D) and NES (E, F).