Phylogenetic trees of MAGEs.

<p>Two clades are formed: one by Type I MAGE genes; the other by Type II MAGE genes. A, Evolution tree of MAGEs in primates. Gene identifier prefixes with species: h stands for human, c for chimpanzee, o for orangutan and r for rhesus. B, Evolution tree of MAGEs in human and rodents. Rodent gene identifier prefixes with m (stands for mouse) or rat. Genes all in capital letters are from human. The MAGEA subfamily is the most divergent between human and rodents by forming monophyletic clusters of Human A and Rodent A. *, rhesus MAGEB16 however is clustered with MAGEC subfamily (see text). In addition to the conserved MAGEC cluster, new Magec(s) derived from Magea exist in rodents labeled as Rodent C. Trees shown are bootstrap consensus tree with 50% cutoff.