<p>HEK293 cells were transfected with expression plasmids encoding hPanK1α-His (a, b), mPanK1α-His (c, d), hPanK1β-ZsGreen1 (e, f), mPanK1β-ZsGreen1 (g, h), hPanK2-ZsGreen1 (i, j), mPanK2-ZsGreen1 (k, l), hPanK3 (m, n), mPanK3 (o, p) and ZsGreen1 (q-t). PanK proteins are green, cell nuclei were stained with DAPI (blue, b, d) or Hoechst 33342 (blue, f, h, j, l, n, p, r, t). Cotransfection with an expression plasmid encoding Lamin A/C-mCherry (LmnA/C, magenta, f, h, j, l, n, p, r, t) designated nuclear membrane and staining with wheat germ agglutinin (WGA)-Alexa647 designated plasma membrane (white, f, h, j, l, n, p, r, t). The PanK1α constructs were visualized by immunocytochemistry in fixed cells using an anti-His tag antibody (a, b, c, d)....
The pantothenate kinases (PanK) catalyze the first and the rate-limiting step in coenzyme A (CoA) bi...
abstract: Pantothenate kinase-associated neurodegeneration, PKAN, is a neurological disease that is ...
Coenzyme A (CoA) biosynthesis is initiated by pantothenatekinase (PanK) and CoA levels are controlle...
<p>HEK293 cells were transfected with expression plasmids encoding PanK1α partial sequences fused to...
<p>(A) Schematic diagram of human and mouse PanK1α proteins and their mutant derivatives named: hPan...
<p>(A) Schematic diagram of the full length hPanK2(1–570) and derivatives named hPanK2(1–210), hPanK...
<p>PanK1α is sequestered in the nucleus, with preferential association within the nucleolus. PanK1β ...
<p>(A) Identical (black) or conserved (gray) residues between the human and mouse isoforms are indic...
<p>HEK293 cells were transfected with expression plasmids encoding mPanK1α(1–185) fused to ZsGreen1 ...
<p>(A) Schematic diagram of human PanK2 without the MTS and the mutant derivatives named: hPanK2-noN...
<p>(A) HeLa cells were transfected with the expression plasmid pAA303 encoding hPanK2(268–275) fused...
<div><p>The pantothenate kinases (PanK) catalyze the first and the rate-limiting step in coenzyme A ...
<p>HeLa cells were transfected with the expression plasmid pAA275 encoding full-length hPanK2(1–570)...
Coenzyme A (CoA) is an essential co-factor at the intersection of diverse metabolic pathways. Cellul...
<p>(a) The single nucleotide polymorphisms detected in the <i>Pfpank1</i> gene (accession number: PF...
The pantothenate kinases (PanK) catalyze the first and the rate-limiting step in coenzyme A (CoA) bi...
abstract: Pantothenate kinase-associated neurodegeneration, PKAN, is a neurological disease that is ...
Coenzyme A (CoA) biosynthesis is initiated by pantothenatekinase (PanK) and CoA levels are controlle...
<p>HEK293 cells were transfected with expression plasmids encoding PanK1α partial sequences fused to...
<p>(A) Schematic diagram of human and mouse PanK1α proteins and their mutant derivatives named: hPan...
<p>(A) Schematic diagram of the full length hPanK2(1–570) and derivatives named hPanK2(1–210), hPanK...
<p>PanK1α is sequestered in the nucleus, with preferential association within the nucleolus. PanK1β ...
<p>(A) Identical (black) or conserved (gray) residues between the human and mouse isoforms are indic...
<p>HEK293 cells were transfected with expression plasmids encoding mPanK1α(1–185) fused to ZsGreen1 ...
<p>(A) Schematic diagram of human PanK2 without the MTS and the mutant derivatives named: hPanK2-noN...
<p>(A) HeLa cells were transfected with the expression plasmid pAA303 encoding hPanK2(268–275) fused...
<div><p>The pantothenate kinases (PanK) catalyze the first and the rate-limiting step in coenzyme A ...
<p>HeLa cells were transfected with the expression plasmid pAA275 encoding full-length hPanK2(1–570)...
Coenzyme A (CoA) is an essential co-factor at the intersection of diverse metabolic pathways. Cellul...
<p>(a) The single nucleotide polymorphisms detected in the <i>Pfpank1</i> gene (accession number: PF...
The pantothenate kinases (PanK) catalyze the first and the rate-limiting step in coenzyme A (CoA) bi...
abstract: Pantothenate kinase-associated neurodegeneration, PKAN, is a neurological disease that is ...
Coenzyme A (CoA) biosynthesis is initiated by pantothenatekinase (PanK) and CoA levels are controlle...