Alignment of the amino-terminal sequences of human and mouse PanK isoforms.

<p>(A) Identical (black) or conserved (gray) residues between the human and mouse isoforms are indicated. The amino acids corresponding to the beginning of the catalytic domain of each isoform are indicated in red. The mitochondrial targeting sequence (MTS) of hPanK2 is indicated in yellow, and the nuclear localization signals (NLS) are highlighted in cyan. (B) Schematic diagram of human and mouse full-length PanK proteins. The numbers indicate the total length of the PanK proteins. The results that follow demonstrate the functionality of nuclear localization signals (NLS) and nuclear export signals (NES), which are highlighted in cyan and orange, respectively.