Effect of <i>Helicobacter pylori</i> infection on fasting blood glucose concentrations in two murine models of obesity.

<p><b>Panel </b><b>A</b>: Fasting blood glucose (FBG) concentrations from leptin receptor-deficient (db/db) mice infected with either the wild-type <i>H. pylori</i> 98–325 (solid line), the isogenic <i>H. pylori</i> 99–305 (dotted line), or uninfected (dashed line), (n = 10 mice/group). Blood was obtained on days 0, 7, 14, 35, 50 and 71 of the study. <b>Panel B</b>: FBG concentrations in a mouse model of diet-induced obesity (DIO). Uninfected (control) mice (dashed line) or mice infected with <i>H. pylori</i> 99–305 (dotted line) are shown. Blood was obtained on days 0, 7, 14, 21 and 60 of the study. <b>Panels C & D</b> illustrate the area under the curve calculations for FBG concentrations in the db/db and DIO models, respectively. Statistically significant (<i>P</i><0.05) differences with the uninfected control mice are indicated (*), (n = 10 mice/group).