PI5Kα signaling controls thermal and capsaicin nociception <i>in vivo</i>.

<p>(A) Thermal pain thresholds of wild type (WT) and <i>PIP5Kα</i>^−/− (KO) littermates in response to radiant heat (Hargreaves; n = 6 for WT; n = 6 for KO mice). (B) <i>PIP5Kα</i> KO mice also show enhanced thermal sensitivity in the hot plate assay (n = 12 for WT; n = 12 for KO mice) and (C) an exaggerated capsaicin-evoked behavioral response (n = 12 for WT; n = 9 for KO mice). (D) PIP5Kα KO mice exhibited normal mechanical pain (force threshold latency) as assessed by the von Frey test (n = 9 for WT; n = 9 for KO mice). All data are presented as mean +/− sem. *<i>p</i><0.05; **<i>p</i><0.01 (t-test).