<p>Figure (A) shows three hypothetical promoters for which the predictions of the promoter design are either numerically correct (), underestimated (▾) or overestimated (). The three smaller figures in (B) show the expected result as repressors are added in a simple repression architecture. The predicted theory line and the data points differ on average by the same percent as they do at .</p
<p>(<b>A</b>) Time- and circumference-averaged Hb (, solid lines) and Kni (, dashed lines) total pro...
<p>The predictions are derived by examining the formulas for these parameters as shown in <a href="h...
<p>Dashed lines and small squares represent fixed weights with <i>N</i> = 7,000. Solid lines and sma...
<p>(A) Schematic of a single target promoter sharing TFs with multiple competitor sites. (B) The var...
<p>(A) Solid surface: predicted gene expression of <a href="http://www.ploscompbiol.org/article/info...
<p>For rescaled activator concentrations and corresponding to a point ‘above’ (‘below’) the hyperb...
<p>Given just 26 noisy data points of cI protein (vermillion diamonds, bottom left) we were able to ...
<p>Modeling results for an activating system (<b>A-D</b>) and a repressing system (<b>E-H</b>) are s...
<p>The values of the parameters , and initial conditions of the six variables used to generate the ...
<p><b>Copyright information:</b></p><p>Taken from "Construction and model-based analysis of a promot...
<p>At a significance level of 0.05 (red) and 0.1 (blue) a. positive regulation, top 30 potential reg...
<p>The line indicates where the predicted values = observed values i.e. the model is a perfect fit...
<p>Average number of mRNA copies (black lines) and the associated standard deviations (blue lines)...
<p>We simulate 1,000 meta-analysis of 10 studies with varying sample sizes where only a subset of th...
<p>a) Predicted relationship between mean and variance using original model with original parameter ...
<p>(<b>A</b>) Time- and circumference-averaged Hb (, solid lines) and Kni (, dashed lines) total pro...
<p>The predictions are derived by examining the formulas for these parameters as shown in <a href="h...
<p>Dashed lines and small squares represent fixed weights with <i>N</i> = 7,000. Solid lines and sma...
<p>(A) Schematic of a single target promoter sharing TFs with multiple competitor sites. (B) The var...
<p>(A) Solid surface: predicted gene expression of <a href="http://www.ploscompbiol.org/article/info...
<p>For rescaled activator concentrations and corresponding to a point ‘above’ (‘below’) the hyperb...
<p>Given just 26 noisy data points of cI protein (vermillion diamonds, bottom left) we were able to ...
<p>Modeling results for an activating system (<b>A-D</b>) and a repressing system (<b>E-H</b>) are s...
<p>The values of the parameters , and initial conditions of the six variables used to generate the ...
<p><b>Copyright information:</b></p><p>Taken from "Construction and model-based analysis of a promot...
<p>At a significance level of 0.05 (red) and 0.1 (blue) a. positive regulation, top 30 potential reg...
<p>The line indicates where the predicted values = observed values i.e. the model is a perfect fit...
<p>Average number of mRNA copies (black lines) and the associated standard deviations (blue lines)...
<p>We simulate 1,000 meta-analysis of 10 studies with varying sample sizes where only a subset of th...
<p>a) Predicted relationship between mean and variance using original model with original parameter ...
<p>(<b>A</b>) Time- and circumference-averaged Hb (, solid lines) and Kni (, dashed lines) total pro...
<p>The predictions are derived by examining the formulas for these parameters as shown in <a href="h...
<p>Dashed lines and small squares represent fixed weights with <i>N</i> = 7,000. Solid lines and sma...