An example of a cross-domain interface in a multi-interface domain.

<p>The two interfaces are colored by orange and forest, respectively. The forest colored interface is a cross-domain interface formed by the interaction between chain H (rendered by surface) and chain G (rendered by cartoon). Chain H has two domains, which are Hemochromatosis protein Hfe -1 and 2 domain (the left part of chain H) and Hemochromatosis protein Hfe -3 domain (the right part of chain H).