A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contact with many other domains, forming a hub in domain-domain interaction networks. The functions played by the multiple interfaces are usually different, but there is no strict bijection between the functions and interfaces as some subsets of the interfaces play the same function. This work applies graph theory and algorithms to discover fingerprints for the multiple interfaces of a domain and to establish associations between the interfaces and functions, based on a huge set of multi-interface proteins from PDB. We found that about 40 % of proteins have the multi-interface property, however the involved multi-interface domains account for only ...
Inter-domain linkers (IDLs)' bridge flanking domains and support inter-domain communication in multi...
ABSTRACT Using a data set of aligned protein domain superfamilies of known three-dimensional structu...
peer reviewedDomains are the building blocks of proteins and play a crucial role in protein-protein ...
A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contac...
A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contac...
<div><p>A multi-interface domain is a domain that can shape multiple and distinctive binding sites t...
A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contac...
<p>Domain <i>a</i> of protein <i>A</i> interacting with domain <i>b</i> of protein <i>B</i> produces...
Intra-chain domain interactions are known to play a significant role in the function and stability o...
The diverse range of cellular functions is performed by a limited number of protein folds existing i...
International audienceInter-domain linkers (IDLs)' bridge flanking domains and support inter-domain ...
International audienceInter-domain linkers (IDLs)' bridge flanking domains and support inter-domain ...
International audienceInter-domain linkers (IDLs)' bridge flanking domains and support inter-domain ...
International audienceInter-domain linkers (IDLs)' bridge flanking domains and support inter-domain ...
© 2012 The Authors. This paper was published in PLoS ONE and is made available as an electronic repr...
Inter-domain linkers (IDLs)' bridge flanking domains and support inter-domain communication in multi...
ABSTRACT Using a data set of aligned protein domain superfamilies of known three-dimensional structu...
peer reviewedDomains are the building blocks of proteins and play a crucial role in protein-protein ...
A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contac...
A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contac...
<div><p>A multi-interface domain is a domain that can shape multiple and distinctive binding sites t...
A multi-interface domain is a domain that can shape multiple and distinctive binding sites to contac...
<p>Domain <i>a</i> of protein <i>A</i> interacting with domain <i>b</i> of protein <i>B</i> produces...
Intra-chain domain interactions are known to play a significant role in the function and stability o...
The diverse range of cellular functions is performed by a limited number of protein folds existing i...
International audienceInter-domain linkers (IDLs)' bridge flanking domains and support inter-domain ...
International audienceInter-domain linkers (IDLs)' bridge flanking domains and support inter-domain ...
International audienceInter-domain linkers (IDLs)' bridge flanking domains and support inter-domain ...
International audienceInter-domain linkers (IDLs)' bridge flanking domains and support inter-domain ...
© 2012 The Authors. This paper was published in PLoS ONE and is made available as an electronic repr...
Inter-domain linkers (IDLs)' bridge flanking domains and support inter-domain communication in multi...
ABSTRACT Using a data set of aligned protein domain superfamilies of known three-dimensional structu...
peer reviewedDomains are the building blocks of proteins and play a crucial role in protein-protein ...