DNA methylation analysis of genetic subregions.

<p>(A) Histograms showing the distribution of promoter methylation in several tissue samples, as indicated. Average methylation levels were determined for all promoters (≥3 CpGs, coverage ≥3 reads) and then distributed into bins with increasing methylation ratios. (B) Histograms showing the distribution of CpG island-associated promoters. Average methylation levels were determined (>5 CpGs, coverage ≥3 reads) and then distributed into bins with increasing methylation ratios. (C) Average DNA methylation ratios of promoters, gene bodies and intergenic regions.