Loss of apoE exacerbates axonal injury after mrTBI.

<p>Axonal damage following mrTBI was assessed with silver staining (arrows). The left panel depicts representative images of silver-stained coronal sections at approximately −1.58 mm from bregma <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053529#pone.0053529-Paxinos1" target="_blank">[66]</a> of untreated WT (<b>A</b>) and apoE−/− (<b>B</b>) mouse brains harvested at 7 d post-mrTBI. White matter areas with prominent silver staining are indicated by the black squares. Injury location is indicated by the arrowhead. The right panel (<b>C–L</b>) depicts representative 40x-magnified images of silver staining in five white matter areas in the brains of untreated WT (<b>C–G</b>) and apoE−/− (<b>H–L</b>) mice harvested at 7 d post-mrTBI.