Top four most abundant transcripts are shared by SLE patients with the H2 full risk haplotype.

<p><i>A,</i> Relative abundance ranking of transcripts from 4 healthy donors, 1 SLE patient with the H3 full protective haplotype, and 4 SLE patients with the H2 full risk haplotype is shown. Transcripts were ranked from most to least abundant using MMSeq-generated Gibbs expression estimates; individual transcripts are represented by distinct colors. <i>B,</i> Hierarchial clustering was performed on the nine samples using expression profiles of the 18 <i>IRF5</i> transcript variants. Height represents the difference between samples. Red values are AU <i>p</i>-values and green values are BP values. Clusters with AU larger than 95% are statistically significant with a <i>p</i><0.05.