Alignments between the HBV RNAseH and the HIV-1 RNAseH and integrase.

<p>Manually optimized alignments between HBV RNAseH and <b>A.</b> the HIV-1 RNAseH, or <b>B.</b> the HIV-1 integrase. The HBV genotype D sequence is from Genbank entry V01460 and the HIV-1 sequences are from strain HXB2; Genbank K03455.1. Identical residues are shaded in black and similar residues are shaded in gray. * indicates the conserved nucleotidly transferase superfamily active site carboxylates (D-E-D-D for the RNAseH enzymes and D-D-E for the integrase). The numbering for each sequence is indicated at top. Residue 1 for the HBV RNAseH domain is amino acid 684 in the full-length polymerase protein (strain adw2) and residue 1 for the HIV-1 RNAseH domain is amino acid 441 of the full-length reverse transcriptase (strain HXB2).