Heat maps of the largest 16 consensus clusters in the DMM time course.

<p>Rows represent genes and columns are time point replicates in the following order: 2 weeks rep2, rep3; 4-, 8- and 16 weeks rep1, rep2, rep3. Red indicates up-regulation, blue down-regulation and white indicates no change in expression from the sham time-matched control. All heat maps in this figure are colored on the same scale for easy comparison with maximum up-regulation at 1.7 SLR and maximum down-regulation at −1.3 SLR. A variety of expression patterns are present with most including significant up-regulation at 4 weeks. Only four clusters contain down-regulated genes (clusters 5, 7, 10 and 12), and cluster 15 is the only one with significant up-regulation 16 weeks after surgery.