Boxplots of TFV and TFV-DP concentrations by anatomic site.

<p>Side-by-side boxplots of end-of-period visit data for all participants by anatomic site and dosing regimen are shown. Each box indicates the interquartile range with center bar as median and whiskers 1.5 times the quartile. *Lower quartile (LQ) is below the limit of quantitation (LOQ), only median and above are shown. **Median is below LOQ, so the median of values above the LOQ are shown as a single bar. X-axis key: <i>anatomic location</i>, PBMC peripheral blood mononuclear cells, CVL cervicovaginal lavage, ECC endocervical cytobrush; <i>drug moiety</i>, TFV tenofovir, TFV-DP tenofovir diphosphate; <i>sample timing</i>, C_max peak concentration following dose at clinic visit, C_pre-dose concentration prior to dose at clinic visit, C_all pools values from all participants regardless of scheduled time relative to dose.