CD28 expression in T cell population from chagasic patients and uninfected controls.

<p>Representative density plots of CD28 expression on CD4+ (<b>A</b>) and CD8+ (<b>B</b>) T cells in chagasic patients (CP), healthy controls (HC) and non-chagasic cardiomyopathy (NCC) donors. The percentage of CD28+ T cells is shown next to each gate. Averaged percentage of total CD4+ (<b>C</b>) and CD8+ (<b>D</b>) T cells expressing CD28 in non-CARD (black dots, n = 11) and CARD (black dots, n = 7) chagasic patients, healthy controls (empty squares, n = 13) and non-chagasic cardiomyopathy (empty triangles, n = 9) donors. (<b>E</b>) Regression analysis between the frequency of CD4+CD28− and the fraction CD8+/CD38+/HLA-DR+ T cells in chagasic patients (non-CARD and CARD). P and <i>r</i> value are shown. * <i>P</i><0.05 and ** <i>P</i><0.001.