Proliferative capacity of T cell populations from chagasic patients and uninfected controls.

<p>Averaged proliferative indexes with standard deviations of CD8+ T lymphocytes (<b>A</b>) in non-CARD (black bars, n = 7) and CARD (black bars, n = 7) chagasic patients (CP), healthy controls (HC, grey bars, n = 6) and non-chagasic cardiomyopathy (NCC, empty bars, n = 6) donors after PHA stimulation. Representative histograms of CFSE fluorescence intensity for CD8+ T cells (<b>B</b>) in chagasic patients (dark histogram), healthy controls (grey histogram) and non-chagasic cardiomyopathy donors (empty histogram). The generation number (G0 through G6) is displayed. (<b>C</b>) Stimulation indexes (% of divided cells with parasite lysate/% of divided cells with medium alone) from non-CARD (black dots, n = 7) and CARD (black dots, n = 7) chagasic patients, healthy controls (HC, empty squares, n = 5) and non-chagasic cardiomyopathy (NCC, empty triangles, n = 5) donors are shown. Note that the CD4+ and CD8+ T cells from the same 2 non-CARD and 2 CARD CP respond to parasite lysate (dotted line and squares). * <i>P</i><0.05.