Δ-CT IQGAP1 stimulates spine formation.
- Ignacio Jausoro (282814)
- Ivan Mestres (282815)
- Gonzalo Quassollo (282816)
- Lujan Masseroni (282817)
- Florencia Heredia (282818)
- Alfredo Caceres (5651311)
Publication date
February 2013
DOIAbstract
<p>(A) Confocal image showing an example of a 17 DIV cultured hippocampal neuron transfected with myc-tagged Δ-CT-IQGAP1 plus GFP (green) and double stained with MAP2 (red). (B) A high magnification view of dendritic segments from another neuron of the same culture; (C) A 3-D reconstruction of dendritic shafts from a sister culture. (D–F) Confocal images showing a dendritic segment from a neuron co-transfected with myc-tagged-Δ-CT-IQGAP1 (blue) plus GFP-PSD95 (green) and stained for synaptophysin (red). (G) Merge image. (H–J) Graphs showing the effect of expressing myc-tagged-Δ-CT-IQGAP1 on spine number/type and spine head size and length. Bars represent mean ± standard deviation. *p<0.0001.</p
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