The effect of SIRT1 expression on dendritic spine density.

<p>(<b>A</b>) Hippocampal Neurons were transfected at 10 DIV and analyzed at 21 DIV. Representative images of dendritic spines in neurons expressing GFP, SIRT1/GFP or SIRT1H363Y/GFP. (<b>B</b>) Dendritic spine density (per 10 µm) in transfected neurons at 21 DIV. (<b>C</b>) Density of the different kinds of dendritic spines (per 10 µm) in transfected neurons. <i>p</i> values were determined by Kruskal-Wallis/Dunn. Error bars indicate S.E.M. n = 40 neurons. *p<0.01; **p<0.001.