Astrocytic structural alterations are prominent in GK rats.

<p>(A) Representative images showing GFAP stained astrocytes (in red) wrapping around the vessels perfused with FITC (in green). GK rats groups have decreased number of astrocytes with more perivascular projection and smaller soma. (B) Diabetic rats show increased astrocytic surface density in both cortex and striatum compared to the control group. F values are indicated under each ANOVA analysis group. *p<0.005 vs control or treatment. Mean ± SEM, n = 3−4.