Changes of (A) concentration-response curves of Y27632 on noradrenaline (NA)-induced contraction in aortic rings from the control group and (B) effects of Y27632 on NA-induced contraction in aortic rings from LPS1h and LPS2h groups are presented.

<p>(A) Depicted are various concentrations of ROK inhibitor Y27632 (10 nmol/L – 0.3 µmol/L) on NA-induced contraction in aortic rings from the control group (0.9% NaCl, infusion 10 min, <i>n</i> = 7 for each groups). (B) Depicted are 0.1 µmol/L Y27632 on NA (1 nmol/L – 30 µmol/L)-induced contraction in aortas from LPS groups (lipopolysaccharide, LPS 10 mg/kg; infusion 10 min; rats were sacrificed at 1 h or 2 h after LPS, <i>n</i> = 5 for each group). Data are expressed as mean ± SEM. *<i>P</i><0.05, with vs. without Y27632.