Participation of NO on the vasodilator response to acetylcholine.

<p>Effect of L-NAME (100 µM) on the concentration-dependent relaxation to ACh in control (A) and tranilast-treated (B) mesenteric resistance arteries. Insert graph shows the differences of area under the curve (dAUC) in control and tranilast-treated arteries pre-treated with L-NAME. Results are expressed as mean ± SEM. N = 6–7 animals in each group. (C) Vasodilator response to DEA-NO in control and tranilast-incubated mesenteric resistance arteries, precontracted with either noradrenaline or KCl. Results are expressed as mean ± S.E.M. N = 5–6 animals each group. (D) Effect of tranilast on basal and acetylcholine-induced NO release in rat mesenteric resistance arteries. Results (mean ± S.E.M.) are expressed as arbitrary fluorescence units (A.U.)/mg tissue. N = 4 animals each group. *P<0.05 vs. basal.