Runx2 protein immunoreactivity is rhythmic in the SCN and PVN of wild type mice.

<p>Fold change (mean ± SEM) in Runx2 protein levels measured by immunodensity analyses in the SCN (A) and PVN (D) of mice housed in 24 h DD. Data are expressed as the fold change (mean ± SEM) relative to the overall mean across times of day for all animals for each brain region. . Significant peaks levels of expression (*) compared to nadir points (#; <i>p</i><0.05). Representative images of sections through the SCN (B and C) and PVN (E and F) at peak (B and E) and nadir (C and F) time points. Traces represent area of analyses. 3V: third ventricle; och: optic chiasm. Scale bar: 100 µm.