Increased percentage of pDCs in blood of NOR and NOD mice.

<p>The presence of pDCs in the blood of C57BL/6, NOD and NOR of 4 and 10 weeks was determined by flow cytometry. Dot plots show the CD11b and PDCA-1 expression (A). Bar graphs represent the percentage of pDCs (CD11b⁻PDCA-1⁺ cells) at 4 weeks (B) and 10 weeks (C). Histograms represent the B220, CD80, CD86, CXCR3, CXCR4 and PD-L1 expression on pDCs in the pancreas of 10 weeks (D). Bar graphs represent the MFI of CD80 (E) and CD86 expression (F) on pDCs at 10 weeks. Data are presented as average+SEM, n = 4–10 mice, * p<0.04, ** p<0.01, *** p<0.001 as determined by the unpaired Mann-Whitney U test.