CD4 or CD8 depletion provides FVB mice protection from LCMV-13 induced death.

<p>FVB mice were treated with anti-CD8 antibody (n = 3), anti-CD4 antibody (n = 3) or PBS (n = 3) at days 0 and 1 post-infection with 1×10⁶ p.f.u. LCMV-13. Survival (A) and weight (B) were monitored daily until day 17 post-infection. Animals were humanely killed upon development of severe disease. C) Serum from 3 mice was combined and analyzed for AST and ALT levels. D) Viral burden in tissues measured after sacrificing animals. Levels of infectious virus in indicated tissue at time of death were quantitated by qRT-PCR for LCMV RNA. Results are presented as mean +/− standard deviation. Results are representative of two independent experiments.