Indications of tissues damage in FVB mice following LCMV infection.

<p>FVB or C57BL/6 mice were infected with 1–2×10⁶ p.f.u. LCMV-13 and blood or tissue samples were taken at day 7 post-infection. A) Histological comparison of infected diseased and normal tissue in FVB mice. Signs of splenic, hepatic and pulmonary necrosis in FVB diseased mice in upper, middle and lower panels, respectively. B) Clinical chemistry profiles of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and blood urea nitrogen (BUN) are shown. LCMV infected C57BL/6 data are presented as the values from combined serum collected from 4–5 mice. LCMV infected FVB data is presented as the mean +/− standard deviation of two groups of 3–5 mice. Results are representative of three independent experiments.