Enriched KEGG pathways among genes in the top 100 interactions.

<p>The top row gives the number of unique genes present in the top 100 miR-mRNA interactions according to each model; the remaining rows give, per column, the number of these genes annotated by <i>KEGG</i> pathway terms with significant enrichment (FDR corrected ) for for at least one of the models proposed. A blank entry indicates that the particular pathway was not significantly enriched in the model. The column <i>G–O</i> refers to the grouped-ordered model version, <i>I–O</i> is the individual-ordered model version, and <i>I-R</i> is the individual-reference model version, while <i>Neg.Cor</i> is the ranking by most negative Pearson correlation (between miR and mRNA expression profiles) among the predicted target pairs. The horizontal lines separate general categories of <i>KEGG</i> pathways, namely cancer-related pathways, other disease-related pathways, and then remaining pathways found to be enriched by at least one of the models.