COX-2 inhibitor treatment initiated 3 weeks after beginning AngII infusion effectively reduces AAA progression in ApoE-deficient mice.

<p>(A) AAA incidence was determined at necropsy following 3 (3 Wks AngII) or 8 weeks (Control and Celecoxib) of AngII infusion. (B) The maximal external diameter or (C) AAA classification of the suprarenal aorta following 3 (3 Wks AngII) or 8 weeks (Control and Celecoxib) of AngII infusion. For aortic diameter, results depict mean ± SEM. AAA incidence and diameter: 3 Wks AngII <i>n</i> = 12, Control <i>n</i> = 13, Celecoxib <i>n</i> = 14. <i>P</i> values were determined for incidence data using Fisher's exact test and an unpaired two-tailed <i>t</i>-test for aortic diameter. * indicates <i>P</i><0.05.