PD123319 augmented AngII-induced suprarenal aortic expansion and incidence of AAAs independent of AT2 receptor genotype.

<p>A. Maximal aortic width of suprarenal aortas was measured ex vivo. Circles and inverted triangles represent values from individual mice, diamonds are mean values of each group, and bars are SEM. * P = 0.01 between AngII-infused and PD123319-infused groups as analyzed by two way ANOVA. There were no significant effects on aortic width for genotypes (AT2 +/y versus AT2 −/y). B. Incidence of AAAs. * P = 0.006 between AngII-infused and PD123319-infused groups as analyzed by Fisher's Exact test. There were no significant effects of genotype (AT2 +/y versus AT2 −/y) on incidence of AAAs.