Distribution of nucleotide and amino acid substitutions observed in the WT and other recombinant virus stocks.

<p>(A) Schematic representation of regions containing N and P genes of indicated virus stocks. Arrows present positions of nucleotide substitutions. Schematic representations of (B) P and (C) C polypeptides. Arrows present positions of amino acid changes compared to that of the original 4C(-), WT, F170S or V(-). Stars indicated reversions of the stop codons introduced in the 4C(-) virus.