<p>The effect of the drugs AZT, EFV and NVP on mutant viruses pNL4-3<sub>T369A</sub> and pNL4-3<sub>T369V</sub> was illustrated. This map was drawn using Graphpad Prism ® software, and the abscissa represents the different drug concentrations (lgnM) and the vertical axis represents the inhibition ratio of drugs on the virus. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047119#pone-0047119-g002" target="_blank"><b>Figure 2a</b></a> Relationship between viral replication and AZT concentration. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047119#pone-0047119-g002" target="_blank"><b>Figure 2b</b></a> Relationship between viral replication and EFV concentration. <a href="http://www.plosone.org...
<p>A) Test compound added during transfection to produce LAI pseudotyped NLRepRlucP373 Δ<i>env</i> a...
Estimated inhibition percentage (A), percentage reduction in the basic reproduction number R0 (B) an...
<p>Each bar shows mean ± SE IC<sub>50</sub> of three replicates. The x-axis shows the viral isolates...
<p>a) Prior to drug exposure, the virus typically does not carry drug-resistance mutations. In the a...
<p><b>A and B:</b> the effects of ongoing viral replication (influenced by the overall drug efficacy...
The relation between direct drug effect η and prophylactic efficacy φ (reduction in infection) is sh...
<p>The HIV strain names are the same as in previous publication <a href="http://www.plosone.org/arti...
<p>(A) Survival time according to molecular viral load at D7; (B) molecular viral load at D7 accordi...
<p><b>(A)</b> A schematic illustrating how a non-preexisting mutant, A’B’, fully resistant to a comb...
<p>(<b>A</b>) An experiment as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/jou...
<p>IIP was calculated using equation (1), with the concentrations used being peak plasma concentrati...
<p>Genotypes had been classified into wild type and mutant. Scatter plots show delta Ct values (thre...
A mathematical model of the interaction among CD4+ T-cells, HIV-1, and antiretroviral drugs was fitt...
Viruses have the ability to spread rapidly because the proteins and enzymes from the host cell help ...
<p>Representative examples of antiviral inhibition curves in a multiple cycle replication assay for ...
<p>A) Test compound added during transfection to produce LAI pseudotyped NLRepRlucP373 Δ<i>env</i> a...
Estimated inhibition percentage (A), percentage reduction in the basic reproduction number R0 (B) an...
<p>Each bar shows mean ± SE IC<sub>50</sub> of three replicates. The x-axis shows the viral isolates...
<p>a) Prior to drug exposure, the virus typically does not carry drug-resistance mutations. In the a...
<p><b>A and B:</b> the effects of ongoing viral replication (influenced by the overall drug efficacy...
The relation between direct drug effect η and prophylactic efficacy φ (reduction in infection) is sh...
<p>The HIV strain names are the same as in previous publication <a href="http://www.plosone.org/arti...
<p>(A) Survival time according to molecular viral load at D7; (B) molecular viral load at D7 accordi...
<p><b>(A)</b> A schematic illustrating how a non-preexisting mutant, A’B’, fully resistant to a comb...
<p>(<b>A</b>) An experiment as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/jou...
<p>IIP was calculated using equation (1), with the concentrations used being peak plasma concentrati...
<p>Genotypes had been classified into wild type and mutant. Scatter plots show delta Ct values (thre...
A mathematical model of the interaction among CD4+ T-cells, HIV-1, and antiretroviral drugs was fitt...
Viruses have the ability to spread rapidly because the proteins and enzymes from the host cell help ...
<p>Representative examples of antiviral inhibition curves in a multiple cycle replication assay for ...
<p>A) Test compound added during transfection to produce LAI pseudotyped NLRepRlucP373 Δ<i>env</i> a...
Estimated inhibition percentage (A), percentage reduction in the basic reproduction number R0 (B) an...
<p>Each bar shows mean ± SE IC<sub>50</sub> of three replicates. The x-axis shows the viral isolates...