Representative antiviral dose-response plots for selected MIs in a multiple cycle antiviral assay.

<p>Representative examples of antiviral inhibition curves in a multiple cycle replication assay for A) BVM, B) BMS-1 and C) BMS-955176 toward WT, V362I, V370A and ΔV370 viruses. Maximal percent inhibition (MPI) values were calculated from the plateaus in inhibition at the highest inhibitor concentration, and tabulated and normalized for multiple experiments in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005990#ppat.1005990.t002" target="_blank">Table 2</a> using the equation MPI = (1 - (signal from the average at the two highest drug concentrations/signal from no drug control) * 100). Units are in <i>Renilla</i> luciferase relative light units (RLU). In cases where there is no curve, and thus no plateau <i>per se</i>, the same calculation method was employed using the two values at the highest compound concentration (6 μM).