Clusters of high lesion frequency in cognitively impaired MS patients.

<p>Yellow shows the clusters of voxels where lesions, after controlling for age and sex, were more frequent (p<0.05, corrected) in cognitively impaired (n = 36) than in cognitively preserved (n = 106) patients with MS (forceps major in A and splenium of the corpus callosum in B). Red shows the clusters of voxels that also survived correction for T2-LV (forceps major, in A). Green represents the WM fiber tract (forceps major, in A) obtained from the FSL probabilistic tractography atlas. Background image is the MNI152 standard space image. Images are shown in radiological convention.