Hyperglycaemia resulted in the up-regulation of 8-OHdG, VEGF and p-STAT3 expression at sites of CNV.

<p>A-B, 8-OHdG, VEGF and p-STAT3 expression patterns at CNV sites in control (Con) and diabetic (DM) mice. CNV lesions were encircled with dashed lines. Relative fluorescence intensities (RFI) of targeted proteins were measured by analysing images of the immunofluorescence staining of serial cross sections of the eyecups. C, Statistical analysis of the data in A and B (*P<0.01); D, Statistical analysis of the data from the VEGF ELISA (*P<0.01).