<p>Black arrows: c-Fos+/TH+ neurons; white arrows: c-Fos-/TH+ neurons (E,F). Quantitative analysis of the number c-Fos+, TH+ or c-Fos +/TH+ neurons (G,H,I). Data are expressed as the mean ± SEM (n = 6–7). +++<i>p</i><0.001 versus the placebo group injected with Tw+Nx; &p<0.05, &&&<i>p</i><0.001 versus morphine+Tw+Nx.</p
<p>ADX and non-operated (sham) rats were made dependent on morphine (mor) for 10 days. Controls rece...
<p>Photographs represent immunohistochemical detection of FosB/ΔFosB in the PVN (A-D), and NTS (F-I)...
<p>(A) A sample slice showing Fos-expression in the NTS. (B) A magnified image of the rectangle in (...
<p>(A, D) Schematic anatomic representation of the PVN and NTS adapted from Paxinos and Watson atlas...
<p>Rats were pretreated with the selective OX1R antagonist SB334867 20 min prior naloxone injection ...
<p>Representative traces show the RMP and SDR of three LC neurons before and 5 min after naloxone su...
<p>ADX and non-operated (sham) rats were made dependent on morphine (mor) for 10 days. Controls rece...
<p>The immunoreactivity corresponding to TH phospho-Ser31 or TH phospho-Ser40 is expressed as a perc...
<p>Mice underwent cardiac perfusions with 4% PFA 2 h following naloxone precipitated withdrawal and ...
<p>(A-E) Fluorescent images of EGFP labeled cells and multiple neurogenesis markers: Nestin, Sox2, N...
<p>Representative traces show the spontaneous discharge activity of three LC neurons before and 5 mi...
Dopamine neurons originating in the VTA are fundamental in the pathophysiology of opiate dependence....
<p>PVN tissue isolated from placebo or morphine-dependent rats pretreated with vehicle or prazosin b...
<p>ADX and non-operated (sham) rats were made dependent on morphine (mor) for 10 days. Controls rece...
<p>The samples traces of sEPSCs before and after application of naloxone (1 μM) in LC neurons of HZ ...
<p>ADX and non-operated (sham) rats were made dependent on morphine (mor) for 10 days. Controls rece...
<p>Photographs represent immunohistochemical detection of FosB/ΔFosB in the PVN (A-D), and NTS (F-I)...
<p>(A) A sample slice showing Fos-expression in the NTS. (B) A magnified image of the rectangle in (...
<p>(A, D) Schematic anatomic representation of the PVN and NTS adapted from Paxinos and Watson atlas...
<p>Rats were pretreated with the selective OX1R antagonist SB334867 20 min prior naloxone injection ...
<p>Representative traces show the RMP and SDR of three LC neurons before and 5 min after naloxone su...
<p>ADX and non-operated (sham) rats were made dependent on morphine (mor) for 10 days. Controls rece...
<p>The immunoreactivity corresponding to TH phospho-Ser31 or TH phospho-Ser40 is expressed as a perc...
<p>Mice underwent cardiac perfusions with 4% PFA 2 h following naloxone precipitated withdrawal and ...
<p>(A-E) Fluorescent images of EGFP labeled cells and multiple neurogenesis markers: Nestin, Sox2, N...
<p>Representative traces show the spontaneous discharge activity of three LC neurons before and 5 mi...
Dopamine neurons originating in the VTA are fundamental in the pathophysiology of opiate dependence....
<p>PVN tissue isolated from placebo or morphine-dependent rats pretreated with vehicle or prazosin b...
<p>ADX and non-operated (sham) rats were made dependent on morphine (mor) for 10 days. Controls rece...
<p>The samples traces of sEPSCs before and after application of naloxone (1 μM) in LC neurons of HZ ...
<p>ADX and non-operated (sham) rats were made dependent on morphine (mor) for 10 days. Controls rece...
<p>Photographs represent immunohistochemical detection of FosB/ΔFosB in the PVN (A-D), and NTS (F-I)...
<p>(A) A sample slice showing Fos-expression in the NTS. (B) A magnified image of the rectangle in (...