Effects of adrenalectomy on FosB/ΔFosB protein expression in the PVN and NTS-A₂ from morphine-dependent rats.

<p>Photographs represent immunohistochemical detection of FosB/ΔFosB in the PVN (A-D), and NTS (F-I) neurons from sham-operated and ADX rats pretreated with placebo (pla) or morphine (mor) pellets for 10 days. Scale bar: 100 µm (70X, low magnification); 20 µm (200X, high magnification). 3 V, third ventricle; AP, area postrema; CC, canal central. Data represent the mean ± SEM (percent of control). E, J: quantitative analysis of FosB/ΔFosB-IR in the PVN and NTS, respectively. *p<i><</i>0.05 ***p<i><</i>0.001 versus sham+placebo; ^#p<i><</i>0.05, ^###p<i><</i>0.001 versus ADX+placebo; ⁺p<0.05 versus sham+morphine.