Basic Characteristics of DIO mice treated with Hif-1a ASO and control ASO compared to untreated animals.

List of genes differently expressed in animals with pharmacologically or genetically inhibited HO-1, 3 days after wounding.

Anna Grochot-Przeczek (372427)
Radoslaw Lach (372428)
Jacek Mis (372429)
Klaudia Skrzypek (372430)
Malgorzata Gozdecka (372431)
Patrycja Sroczynska (372432)
Milena Dubiel (372433)
Andrzej Rutkowski (170103)
Magdalena Kozakowska (372436)
Anna Zagorska (372437)
Jacek Walczynski (372439)
Halina Was (94523)
Jerzy Kotlinowski (372440)
Justyna Drukala (372441)
Krzysztof Kurowski (372442)
Claudine Kieda (350811)
Yann Herault (1783081)
Jozef Dulak (94525)
Alicja Jozkowicz (94524)

February 2013

Presence of proteins in the serum of mice was analyzed using RayBiotech arrays followed by densit...

Antisense oligonucleotide (ASO) mediated knock-down of IL-1Ra transcript in vitro and in vivo using locked nucleic acids (LNAs).

Niclas Franck (632562)
Michael Maris (583479)
Sarah Nalbandian (632563)
Saswata Talukdar (359777)
Simon Schenk (632564)
Hans-Peter Hofmann (632565)
David Bullough (632566)
Olivia Osborn (632567)

September 2014

A) QPCR analysis of IL-1Ra mRNA expression after ASO treatment in Hepa 1–6 cells, each concentrat...

General characteristics, plasma, and hepatic metabolite levels.

Fang Yan (134746)
Qi Wang (22418)
Chao Xu (201376)
Mingfeng Cao (577797)
Xiaoming Zhou (308488)
Tingting Wang (123983)
Chunxiao Yu (561760)
Fei Jing (298892)
Wenbin Chen (90534)
Ling Gao (429702)
Jiajun Zhao (577798)

June 2014

Values are given as the mean ± SD. for n = 6; *, p<0.05 vs. control mice.</p

Fasting blood glucose (A) and serum insulin (B), leptin (C), adiponectin (D), fasting serum cholesterol (E) and triglycerides (F), liver cholesterol (G) and triglycerides (H) in DIO mice treated with HIF-1α ASO, control ASO or observed untreated.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

* and † denote p<0.05 and 0.01, respectively, for the difference with HIF-1α ASO treated mice.</p

Energy Expenditure (EE, panel A) and Respiratory Exchange Ratio (RER, panel B) in DIO mice treated with HIF-1α ASO, control ASO or observed untreated during the dark and light phases.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

* denotes p<0.001 for the difference with HIF-1α ASO treated mice; † denotes p<0.001 for the diff...

Western blot for HIF-1α in the livers (panel A) and epididymal fat (panel B) of mice with diet-induced obesity (DIO) treated with HIF-1α antisense oligonucleotides (ASO), control ASO (Con) or observed untreated (U) for 8 weeks.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

N = 5 per group. Representative samples shown. High fat diet was administered for 12 weeks prior ...

The intraperitoneal glucose tolerance test (A) and insulin tolerance test (B) were performed in DIO mice treated with HIF-1α ASO, control ASO or observed untreated.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

The hyperinsulinemic euglycemic clamp was performed in HIF-1α ASO treated and untreated mice (C, ...

Expression of hypoxia inducible factor 1 alpha (HIF-1α, panel A) and a canonical HIF-1 regulated gene, Glut-1 (panel B) in different tissues of C57BL/6J mice with diet induced obesity (DIO) treated with HIF-1α antisense oligonucleotides (HIF-1α ASO), control ASO or observed untreated for 8 weeks.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

High fat diet was administered for 12 weeks prior to the ASO treatment and continued during the t...

Mouse models in this study.

Joo Young Kim (128707)
Jung-Ho Sohn (689986)
Jae-Hyun Lee (128715)
Jung-Won Park (128726)

February 2015

(a) Scheme of this study. C57BL/6 mice fed HFD for 16 weeks and some of the DIO mice underwent OV...

Non-fasting glucose levels, hemoglobin A1c (HbA1c), and glucose tolerance test of DIO mice treated with Genz-112638.

Nelson S. Yew (363847)
Hongmei Zhao (250090)
Eun-Gyoung Hong (363850)
I-Huan Wu (363852)
Malgorzata Przybylska (363854)
Craig Siegel (363855)
James A. Shayman (359510)
Cynthia M. Arbeeny (363856)
Jason K. Kim (188089)
Canwen Jiang (363857)
Seng H. Cheng (142952)

February 2013

A) DIO mice were treated with Genz-112638 or placebo (water) by daily oral gavage at 75 or 125 mg...

Effects of DIO on metabolic parameters in mice lacking αCGRP.

Alexander Bartelt (320188)
Anke Jeschke (297345)
Brigitte Müller (371581)
Isabella Gaziano (4217893)
Michelle Morales (4217890)
Timur Yorgan (1304625)
Timo Heckt (671843)
Markus Heine (266203)
Robert F. Gagel (4217896)
Ronald B. Emeson (4217899)
Michael Amling (133377)
Andreas Niemeier (284738)
Jörg Heeren (3699403)
Thorsten Schinke (126724)
Johannes Keller (297344)

June 2017

(a) Body weight in αCGRP-deficient mice and controls fed HFD for 16 weeks. (b) Orga...

Accumulation of glycogen during HIF-1α ASO treatment.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

(A) Representative images of liver sections in HIF-1α ASO treated (upper panel), control A...

Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1

Elaine Pirie (5904584)
Shayoni Ray (179927)
Calvin Pan (22416)
Wuxia Fu (5904587)
Andrew F. Powers (5904590)
Danielle Polikoff (5904593)
Colton M. Miller (2621233)
Katrina M. Kudrna (5904596)
Edward N. Harris (2621230)
Aldons J. Lusis (108077)
Rosanne M. Crooke (361540)
Richard G. Lee (505771)

November 2018

Antisense oligonucleotides (ASOs) have demonstrated variation of efficacy in patient populations. Th...

Lack of DAO activity suppresses IRI-induced accumulation of D-serine in serum.

Jumpei Sasabe (516628)
Masataka Suzuki (516629)
Yurika Miyoshi (516630)
Yosuke Tojo (516631)
Chieko Okamura (516632)
Sonomi Ito (516633)
Ryuichi Konno (516634)
Masashi Mita (516635)
Kenji Hamase (516636)
Sadakazu Aiso (424134)

January 2014

(A-C) The serine enantiomers in the sera of DAO-null mice were determined using 2D-HPLC, and thei...

Biochemical serum analysis of JD treated mice.

Cong Wang (107450)
Liping Jiang (306239)
Saiqi Wang (759166)
Hongge Shi (759167)
Junwei Wang (239285)
Ran Wang (169166)
Yongmei Li (227480)
Yinhui Dou (759168)
Ying Liu (18461)
Guiqin Hou (759169)
Yu Ke (759170)
Hongmin Liu (759171)

June 2015

A. Concentration of ALT (U/L) in serum of the mice shown as Mean ± SD. B. Concentration of AST (U...

List of genes differently expressed in animals with pharmacologically or genetically inhibited HO-1, 3 days after wounding.

Anna Grochot-Przeczek (372427)
Radoslaw Lach (372428)
Jacek Mis (372429)
Klaudia Skrzypek (372430)
Malgorzata Gozdecka (372431)
Patrycja Sroczynska (372432)
Milena Dubiel (372433)
Andrzej Rutkowski (170103)
Magdalena Kozakowska (372436)
Anna Zagorska (372437)
Jacek Walczynski (372439)
Halina Was (94523)
Jerzy Kotlinowski (372440)
Justyna Drukala (372441)
Krzysztof Kurowski (372442)
Claudine Kieda (350811)
Yann Herault (1783081)
Jozef Dulak (94525)
Alicja Jozkowicz (94524)

February 2013

Presence of proteins in the serum of mice was analyzed using RayBiotech arrays followed by densit...

Antisense oligonucleotide (ASO) mediated knock-down of IL-1Ra transcript in vitro and in vivo using locked nucleic acids (LNAs).

Niclas Franck (632562)
Michael Maris (583479)
Sarah Nalbandian (632563)
Saswata Talukdar (359777)
Simon Schenk (632564)
Hans-Peter Hofmann (632565)
David Bullough (632566)
Olivia Osborn (632567)

September 2014

A) QPCR analysis of IL-1Ra mRNA expression after ASO treatment in Hepa 1–6 cells, each concentrat...

General characteristics, plasma, and hepatic metabolite levels.

Fang Yan (134746)
Qi Wang (22418)
Chao Xu (201376)
Mingfeng Cao (577797)
Xiaoming Zhou (308488)
Tingting Wang (123983)
Chunxiao Yu (561760)
Fei Jing (298892)
Wenbin Chen (90534)
Ling Gao (429702)
Jiajun Zhao (577798)

June 2014

Values are given as the mean ± SD. for n = 6; *, p<0.05 vs. control mice.</p

Fasting blood glucose (A) and serum insulin (B), leptin (C), adiponectin (D), fasting serum cholesterol (E) and triglycerides (F), liver cholesterol (G) and triglycerides (H) in DIO mice treated with HIF-1α ASO, control ASO or observed untreated.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

* and † denote p<0.05 and 0.01, respectively, for the difference with HIF-1α ASO treated mice.</p

Energy Expenditure (EE, panel A) and Respiratory Exchange Ratio (RER, panel B) in DIO mice treated with HIF-1α ASO, control ASO or observed untreated during the dark and light phases.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

* denotes p<0.001 for the difference with HIF-1α ASO treated mice; † denotes p<0.001 for the diff...

Western blot for HIF-1α in the livers (panel A) and epididymal fat (panel B) of mice with diet-induced obesity (DIO) treated with HIF-1α antisense oligonucleotides (ASO), control ASO (Con) or observed untreated (U) for 8 weeks.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

N = 5 per group. Representative samples shown. High fat diet was administered for 12 weeks prior ...

The intraperitoneal glucose tolerance test (A) and insulin tolerance test (B) were performed in DIO mice treated with HIF-1α ASO, control ASO or observed untreated.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

The hyperinsulinemic euglycemic clamp was performed in HIF-1α ASO treated and untreated mice (C, ...

Expression of hypoxia inducible factor 1 alpha (HIF-1α, panel A) and a canonical HIF-1 regulated gene, Glut-1 (panel B) in different tissues of C57BL/6J mice with diet induced obesity (DIO) treated with HIF-1α antisense oligonucleotides (HIF-1α ASO), control ASO or observed untreated for 8 weeks.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

High fat diet was administered for 12 weeks prior to the ASO treatment and continued during the t...

Mouse models in this study.

Joo Young Kim (128707)
Jung-Ho Sohn (689986)
Jae-Hyun Lee (128715)
Jung-Won Park (128726)

February 2015

(a) Scheme of this study. C57BL/6 mice fed HFD for 16 weeks and some of the DIO mice underwent OV...

Non-fasting glucose levels, hemoglobin A1c (HbA1c), and glucose tolerance test of DIO mice treated with Genz-112638.

Nelson S. Yew (363847)
Hongmei Zhao (250090)
Eun-Gyoung Hong (363850)
I-Huan Wu (363852)
Malgorzata Przybylska (363854)
Craig Siegel (363855)
James A. Shayman (359510)
Cynthia M. Arbeeny (363856)
Jason K. Kim (188089)
Canwen Jiang (363857)
Seng H. Cheng (142952)

February 2013

A) DIO mice were treated with Genz-112638 or placebo (water) by daily oral gavage at 75 or 125 mg...

Effects of DIO on metabolic parameters in mice lacking αCGRP.

Alexander Bartelt (320188)
Anke Jeschke (297345)
Brigitte Müller (371581)
Isabella Gaziano (4217893)
Michelle Morales (4217890)
Timur Yorgan (1304625)
Timo Heckt (671843)
Markus Heine (266203)
Robert F. Gagel (4217896)
Ronald B. Emeson (4217899)
Michael Amling (133377)
Andreas Niemeier (284738)
Jörg Heeren (3699403)
Thorsten Schinke (126724)
Johannes Keller (297344)

June 2017

(a) Body weight in αCGRP-deficient mice and controls fed HFD for 16 weeks. (b) Orga...

Accumulation of glycogen during HIF-1α ASO treatment.

Mi-Kyung Shin (304678)
Luciano F. Drager (304679)
Qiaoling Yao (304681)
Shannon Bevans-Fonti (304682)
Doo-Young Yoo (304683)
Jonathan C. Jun (304684)
Susan Aja (304685)
Sanjay Bhanot (50171)
Vsevolod Y. Polotsky (304686)

February 2013

(A) Representative images of liver sections in HIF-1α ASO treated (upper panel), control A...

Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1

Elaine Pirie (5904584)
Shayoni Ray (179927)
Calvin Pan (22416)
Wuxia Fu (5904587)
Andrew F. Powers (5904590)
Danielle Polikoff (5904593)
Colton M. Miller (2621233)
Katrina M. Kudrna (5904596)
Edward N. Harris (2621230)
Aldons J. Lusis (108077)
Rosanne M. Crooke (361540)
Richard G. Lee (505771)

November 2018

Antisense oligonucleotides (ASOs) have demonstrated variation of efficacy in patient populations. Th...

Lack of DAO activity suppresses IRI-induced accumulation of D-serine in serum.

Jumpei Sasabe (516628)
Masataka Suzuki (516629)
Yurika Miyoshi (516630)
Yosuke Tojo (516631)
Chieko Okamura (516632)
Sonomi Ito (516633)
Ryuichi Konno (516634)
Masashi Mita (516635)
Kenji Hamase (516636)
Sadakazu Aiso (424134)

January 2014

(A-C) The serine enantiomers in the sera of DAO-null mice were determined using 2D-HPLC, and thei...

Biochemical serum analysis of JD treated mice.

Cong Wang (107450)
Liping Jiang (306239)
Saiqi Wang (759166)
Hongge Shi (759167)
Junwei Wang (239285)
Ran Wang (169166)
Yongmei Li (227480)
Yinhui Dou (759168)
Ying Liu (18461)
Guiqin Hou (759169)
Yu Ke (759170)
Hongmin Liu (759171)

June 2015

A. Concentration of ALT (U/L) in serum of the mice shown as Mean ± SD. B. Concentration of AST (U...

List of genes differently expressed in animals with pharmacologically or genetically inhibited HO-1, 3 days after wounding.

Anna Grochot-Przeczek (372427)
Radoslaw Lach (372428)
Jacek Mis (372429)
Klaudia Skrzypek (372430)
Malgorzata Gozdecka (372431)
Patrycja Sroczynska (372432)
Milena Dubiel (372433)
Andrzej Rutkowski (170103)
Magdalena Kozakowska (372436)
Anna Zagorska (372437)
Jacek Walczynski (372439)
Halina Was (94523)
Jerzy Kotlinowski (372440)
Justyna Drukala (372441)
Krzysztof Kurowski (372442)
Claudine Kieda (350811)
Yann Herault (1783081)
Jozef Dulak (94525)
Alicja Jozkowicz (94524)

February 2013

Presence of proteins in the serum of mice was analyzed using RayBiotech arrays followed by densit...

Antisense oligonucleotide (ASO) mediated knock-down of IL-1Ra transcript in vitro and in vivo using locked nucleic acids (LNAs).

Niclas Franck (632562)
Michael Maris (583479)
Sarah Nalbandian (632563)
Saswata Talukdar (359777)
Simon Schenk (632564)
Hans-Peter Hofmann (632565)
David Bullough (632566)
Olivia Osborn (632567)

September 2014

A) QPCR analysis of IL-1Ra mRNA expression after ASO treatment in Hepa 1–6 cells, each concentrat...

General characteristics, plasma, and hepatic metabolite levels.

Fang Yan (134746)
Qi Wang (22418)
Chao Xu (201376)
Mingfeng Cao (577797)
Xiaoming Zhou (308488)
Tingting Wang (123983)
Chunxiao Yu (561760)
Fei Jing (298892)
Wenbin Chen (90534)
Ling Gao (429702)
Jiajun Zhao (577798)

June 2014

Values are given as the mean ± SD. for n = 6; *, p<0.05 vs. control mice.</p

Basic Characteristics of DIO mice treated with Hif-1a ASO and control ASO compared to untreated animals.

Abstract

Extracted data

Basic Characteristics of DIO mice treated with Hif-1a ASO and control ASO compared to untreated animals.

Abstract

Extracted data

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