Intrahepatic T cells are cytotoxic against DENV-infected hepatocytes.

<p>(A) Liver lysates were collected from uninfected and infected wild type and TCRβ KO mice. Arrow points to cleaved capase 3. Data presented are representative of three independent experiments (<i>n = </i>3 per time point in each experiment). (B) Uninfected (Uninf) or infected (Inf) Hepa 1–6 were co-cultured with IHLs isolated from uninfected (Uninf) or infected (Inf) mice at different ratio. Data presented are representative of three independent experiments (<i>n = </i>3 per time point in each experiment). (C) Liver cryosections from infected mice at day 5 with or without anti-CD4 and anti-CD8 antibody were stained with TUNEL reagents. Data presented are representative of three independent experiments (<i>n = </i>3 per time point in each experiment).