The effect of silencing DKK-1 on the <i>R. conorii</i>-induced cytokine levels in HUVECs.
- Elisabeth Astrup (307046)
- Tove Lekva (307048)
- Giovanni Davì (307049)
- Kari Otterdal (151355)
- Francesca Santilli (275894)
- Erik Øie (162182)
- Bente Halvorsen (151367)
- Jan Kristian Damås (281943)
- Didier Raoult (3833)
- Giustina Vitale (307053)
- Juan P. Olano (307056)
- Thor Ueland (307058)
- Pål Aukrust (151370)
Publication date
February 2013
DOIAbstract
<p>The figure shows the effect of different concentrations of <i>R. conorii</i> in HUVECs on mRNA expression (left panel) and release of protein in cell supernatants (right panel) of DKK-1 (<b>A</b>), IL-6 (<b>B</b>), IL-8 (<b>C</b>) and GROα (<b>D</b>) in the presence (siDKK, filled bars) and absence (siSCR, open bars) of siRNA probes to silence DKK-1. Silencing for 24 hours plus culturing for 6 (mRNA) and 24 (protein) hours respectively. Data are given as mean±SEM (n = 4). **<i>P</i><.01, ***<i>P</i><.001 <i>vs.</i> siSCR treated cells (control cells). †<i>P</i><.05, ††<i>P</i><.01 and †††<i>P</i><.001 <i>vs</i>. un-stimulated (US) siSCR treated cells.</p
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