TLR2/4 knockout mice are unable to mount CHS responses to TNCB.

<p>(A) WT or TLR2/4 double knock out mice were sensitized with TNCB (3%) or acetone as solvent control and challenged with TNCB (1%) 5 days later. Data show mean increase in ear thickness +/− SD with n = 3 mice/group. One of two independent experiments is shown. (B) Germ-free C57BL/10 mice were treated as in A. Data show mean increase in ear thickness +/− SD of 6 (acetone) or 7 (TNCB) mice. One experiment was performed.