CR1/2 on FDCs are required for a robust IgG anti-SRBC response to SRBC.

<p>BALB/c and <i>Cr2^−/−</i> mice were irradiated and reconstituted with either BALB/c or <i>Cr2^−/−</i> bone marrow. Six weeks after reconstitution, mice (n = 6/group) were immunized i.v. with 5×10⁶, 5×10⁷, or 5×10⁸ SRBC. All mice were bled at indicated time points. Sera were diluted 1∶125 (A) or 1∶625 (B and C) and screened for IgG anti-SRBC in ELISA. P-values represent comparisons between the responses in recipients with the same background; ns = p>0.05; * = p<0.05; ** = p<0.01; *** = p<0.001. Representative of two (A) or one (B, C) experiments.