MDSC depletion augmented the frequency and function of NK and T cell effectors and reduced 3LL lung metastases in tumor bearing mice.

<p><b><i>3A</i></b><i>,</i> H&E and IHC for T cells or GR1 expressing cells in tumor tissues following MDSC depletion or control treatments. <b><i>3B</i></b><i>,</i> H&E of lung sections to evaluate lung metastasis following MDSC depletion. <b><i>3C</i></b><i>,</i> Frequency of tumor infiltrates (CD3, CD4, CD8, CD11c, F480 or CD49b), <b>3</b><b><i>D</i></b><i>,</i> NK cells expressing IFNγ, perforin and granzyme, <b><i>3E</i></b>, CD8 expressing IFNγ, perforin and granzyme but reduced IL-10 expression analyzed by flow cytometry. <b><i>3F</i></b><i>,</i> Tumor cytokine expression <b>(</b>IFNγ, IL-12, TNFα and IL-10) following MDSC depletion. (Data, mean ± SEM, *p<0.05 compared to controls, n = 8 mice/group).