<p>fig:ToyModel: The metabolic reaction network used. The solid arrows represent the base network and dashed lines indicate the additional kinetic interactions considered. fig:ElasticityMatrix: the reference steady state and the kinetic parameters for the small model.</p
Purpose: Modeling metabolic interactions between chemicals can be a formidable model development tas...
<p><b>a</b>) Toy-model: <i>R1</i> to <i>R7</i> and <i>A</i> to <i>D</i> represent reactions and meta...
<p>The toy metabolic network in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journa...
<p>The network consists of seven metabolites and seven irreversible reactions. We assume that metabo...
<p>The first two columns are the physiological space (first colum: flux vs. , second column: vs ), ...
Model-based analysis of enzyme kinetics allows the determination of optimal conditions for their use...
<p>Metabolites are represented by circles and reactions by squares. Colored reactions with black arr...
Mechanistic (also called kinetic) models quantitatively describe dynamic and steady states of bioche...
<p>A schematic of the network of reactions and metabolites of the kinetic model, including the metab...
<p>(A) Independent Equiprobable model. (B) Cooperative Equiprobable model. (C) Independent 1 Slow St...
<p>A schematic showing the different states of the system and the reaction pathways between them. <i...
<p>Glucose metabolism, including the pentose phosphate pathway, glycolysis, and the TCA cycle, was m...
The sense of dynamic nature of a metabolic pathway, particularly in its steady state, is the most di...
To translate metabolic networks into dynamic models, the Structural Kinetic Modelling framework (SKM...
<p>Note that some metabolites participate in only the stoichiometric part of the model (i.e., <b><i>...
Purpose: Modeling metabolic interactions between chemicals can be a formidable model development tas...
<p><b>a</b>) Toy-model: <i>R1</i> to <i>R7</i> and <i>A</i> to <i>D</i> represent reactions and meta...
<p>The toy metabolic network in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journa...
<p>The network consists of seven metabolites and seven irreversible reactions. We assume that metabo...
<p>The first two columns are the physiological space (first colum: flux vs. , second column: vs ), ...
Model-based analysis of enzyme kinetics allows the determination of optimal conditions for their use...
<p>Metabolites are represented by circles and reactions by squares. Colored reactions with black arr...
Mechanistic (also called kinetic) models quantitatively describe dynamic and steady states of bioche...
<p>A schematic of the network of reactions and metabolites of the kinetic model, including the metab...
<p>(A) Independent Equiprobable model. (B) Cooperative Equiprobable model. (C) Independent 1 Slow St...
<p>A schematic showing the different states of the system and the reaction pathways between them. <i...
<p>Glucose metabolism, including the pentose phosphate pathway, glycolysis, and the TCA cycle, was m...
The sense of dynamic nature of a metabolic pathway, particularly in its steady state, is the most di...
To translate metabolic networks into dynamic models, the Structural Kinetic Modelling framework (SKM...
<p>Note that some metabolites participate in only the stoichiometric part of the model (i.e., <b><i>...
Purpose: Modeling metabolic interactions between chemicals can be a formidable model development tas...
<p><b>a</b>) Toy-model: <i>R1</i> to <i>R7</i> and <i>A</i> to <i>D</i> represent reactions and meta...
<p>The toy metabolic network in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journa...