<p><b> on </b><b> on the feasible enzyme space with respect to homeostasis (</b><b>) and function (</b><b>).</b> fig:HomeostasisEv1x2: The feasible enzyme space for (left), (center), and (right). In every subplot, red points: solely homeostatically feasible enzyme levels; blue points: solely functionally feasible enzyme levels; black points: feasible enzyme levels on both criteria. The axes for all 3 plots are the same, enzyme levels relative to the reference state. fig:AdditionalFeedbackEv1x2-MetLev: The maximum achievable metabolite levels as function of the inhibition strength.</p
What is the relationship between enzymes and metabolites, the two major constituents of metabolic ne...
<div><p>(A) In the absence of feedback control, saturation of G by Y causes a sublinear catastrophic...
Most general biochemistry textbooks present enzyme inhibition by showing how the basic Michaelis-Men...
<p>The first two columns are the physiological space (first colum: flux vs. , second column: vs ), ...
In the cost vector plots, panels a) and b), the red vector denotes the optimal solution in the unper...
The local stability of unbranched biosynthetic pathways is examined by mathematical analysis and com...
Inhibition of the aminoacyl-tRNA synthetase by the penultimate product of a pathway for the biosynth...
Background: Rate-limiting enzymes, because of their relatively low velocity, are believed to influen...
<p>(A) Black bars show enzyme control coefficients for the open-loop case, in which wild-type enzyme...
AbstractWe have determined the effects of control by overall feedback inhibition on the systemic beh...
A recently developed, nonlinear method of systems analysis has been used to compare alternative patt...
ABSTRACT We have determined the effects of control by overall feedback inhibition on the systemic be...
<p>fig:ObjSpace represents the objective space, where each feasibility criterion is taken along (no ...
<p>(<b>Left</b>) Simulated progress curves for competitive (blue trace), uninhibited (black trace) r...
What is the relationship between enzymes and metabolites, the two major constituents of metabolic ne...
What is the relationship between enzymes and metabolites, the two major constituents of metabolic ne...
<div><p>(A) In the absence of feedback control, saturation of G by Y causes a sublinear catastrophic...
Most general biochemistry textbooks present enzyme inhibition by showing how the basic Michaelis-Men...
<p>The first two columns are the physiological space (first colum: flux vs. , second column: vs ), ...
In the cost vector plots, panels a) and b), the red vector denotes the optimal solution in the unper...
The local stability of unbranched biosynthetic pathways is examined by mathematical analysis and com...
Inhibition of the aminoacyl-tRNA synthetase by the penultimate product of a pathway for the biosynth...
Background: Rate-limiting enzymes, because of their relatively low velocity, are believed to influen...
<p>(A) Black bars show enzyme control coefficients for the open-loop case, in which wild-type enzyme...
AbstractWe have determined the effects of control by overall feedback inhibition on the systemic beh...
A recently developed, nonlinear method of systems analysis has been used to compare alternative patt...
ABSTRACT We have determined the effects of control by overall feedback inhibition on the systemic be...
<p>fig:ObjSpace represents the objective space, where each feasibility criterion is taken along (no ...
<p>(<b>Left</b>) Simulated progress curves for competitive (blue trace), uninhibited (black trace) r...
What is the relationship between enzymes and metabolites, the two major constituents of metabolic ne...
What is the relationship between enzymes and metabolites, the two major constituents of metabolic ne...
<div><p>(A) In the absence of feedback control, saturation of G by Y causes a sublinear catastrophic...
Most general biochemistry textbooks present enzyme inhibition by showing how the basic Michaelis-Men...