Increased body weight/adiposity despite reduced food intake in Y1Y5^−/− mice on chow.

<p>(A–H) Spontaneous (A, C, E, G) and accumulated (accum) 24-hour fasting-induced food intake (B, D, F, H), normalised to body weight, in male and female germline Y1Y5 receptor knockout (Y1Y5^−/−) and wildtype control (WT) mice at 18 and 34 weeks of age. (I–J) Body weight from 16 to 36 weeks of age in male (I) and female (J) Y1Y5^−/− or WT mice. (K–P) Fat and lean masses as a percentage of body weight (%BW), measured using dual energy x-ray absorptiometry, in male (K, O) and female (M, P) Y1Y5^−/− and WT mice at 20 and 36 weeks of age. Weight (as %BW) of dissected white (WAT) and brown adipose tissue (BAT) depots at the end of the study in male (L) and female (N) Y1Y5^−/− and WT mice at 36 weeks of age. Abbreviations: i, inguinal; g, gonadal; m, mesenteric; r, retroperitoneal; total, summed weight of i, g, m and r WAT depots. Plotted values are means ± SEM of 5–12 standard chow-fed mice per group. *P<0.05, **P<0.01 or ***P<0.001 for Y1Y5^−/− versus WT mice of the same age and sex.