Slower weight regain after a 24-hour fast in Y1Y5^−/− mice on chow.

<p>Body weight measurements were taken at the time points of fasting-induced food intake measurements in male (A, C) and female (B, D) germline Y1Y5 receptor knockout (Y1Y5^−/−) or wildtype control (WT) mice, at both 18 and 34 weeks of age. Data are presented as a percent of pre-fasting body weight (%basal). Absolute pre-fasting body weights at 18 weeks of age were WT male = 25.4±0.6 g; Y1Y5^−/− male = 29.3±1.8 g; WT female = 19.7±0.5 g; Y1Y5^−/− female = 20.1±0.4 g, and at 34 weeks of age, WT male = 30.1±1.3 g; Y1Y5^−/− male = 35.5±1.2 g; WT female = 24.5±0.7 g; Y1Y5^−/− female = 25.0±0.9 g. Plotted values are means ± SEM of 4–21 standard chow-fed mice per group. **P<0.01 or ***P<0.001 for Y1Y5^−/− versus WT mice of the same age and sex.