Acute EGF administration prevented Losartan-mediated inhibition of EGFR phosphorylation in diabetic hearts.

<p><b>a</b>) A representative Western blot showing post-I/R levels of phosphorylated (p-EGFR) and total EGFR (T-EGFR) in diabetic hearts (D) and following acute administration during reperfusion of Losartan (LOS), EGF (EGF) or their combination (EGF+LOS) and b) densitometric histogram quantifying the relative intensity of p-EGFR/t-EGFR following normalization of each molecule to actin. N=4; * significantly different to D and ** significantly different to LOS.