Structure and function of the Genius 75/90 Dialysis System and sample collection.

<p>Patient’s blood runs countercurrent to dialysate and enters the dialysis circuit from a Shaldon catheter. The “arterial”, i.e. predialyser blood line (red) passes the filter and blood flows back to the patient via the “venous”, i.e. post-dialyser blood line (blue). Fresh dialysate is prepared individually for every patient’s conditions and stored in a 75 or 90 liter tank. A tube leads the fresh dialysate (light-blue) to the dialysis filter. Exchange of substances and filtration is mediated by an osmotic and pressure gradient and is supported by counter-flow principle. Spent dialysate (grey) flows through the outlet dialysate line back into the tank. Phase formation prevents the mixture of fresh and spent dialysate. An ultrafiltration pump transports the excess filtrate and maintains the pressure gradient of the system. Samples are taken at the marked locations.