Original Article Temperature and concentration distribution within the Genius dialysate container

Background. The Genius single-pass batch system, using a closed dialysate container, is increasingly applied for dialysis treatment. Although fluid separa-tion between fresh and spent dialysate is maintained in the container during standard dialysis, dialysate mixing may occur under certain clinical conditions. An in vitro study showed that differences in dialysate temperature and solute content between fresh and spent dialysate determine the occurrence and moment of dialysate mixing. Methods. To better understand the maintenance of separation of fresh and spent dialysate in the prevention of mixing, a mathematical model of the 75 l Genius container was developed and the genera